In this presentation, the use of multi-step 3D printing technologies, which incorporate digital micromirror device-based stereolithography, two photon polymerization, pulsed laser deposition, matrix assisted pulsed laser evaporation, piezoelectric inkjet printing, and/or micromolding, to create small-scale medical devices for transdermal drug delivery will be considered. Microneedles are small-scale lancet-shaped devices that may be used for delivery of pharmacologic agents into the skin. We have use 3D printing techniques to microneedles such as digital micromirror device-based stereolithography and two photon polymerization to create microneedles with well-defined tips and complex shapes directly from computer models. Printing techniques including pulsed laser deposition, matrix assisted pulsed laser evaporation, and piezoelectric inkjet printing have been used to decorate the 3D printing microneedles with medically active agents. For example, visible light dynamic mask microstereolithography and micromolding have been used to prepare microneedles out of poly(methyl vinyl ether – co – maleic anhydride) (PMVE/MA); coatings containing agents such as amphotericin B and miconazole have deposited on the microneedles using piezoelectric inkjet printing. Disk-diffusion studies demonstrated the antifungal activity of the inkjet printing-modified microneedle arrays. Examples involving the use of multi-step 3D printed microneedles for various medical applications will be considered.