Nanomanufacturing is the fabrication of nano-scale building-blocks (nanomaterials, nanostructures), their assembly into higher-order structures, and the integration of these into larger scale systems with manipulation and control at nano-scale. Typically, the scale ranges from 1-100 nm. Processes can be top-down (additive/subtractive) or bottom-up (self- and directed-assembly) or an integration of the two. Manufacturing processes need to be scalable, controllable, reproducible, efficient and low cost. The combination of large-scale production and nano-scale products raises environmental and sustainability issues. Questions needing answers are: 1) How can industry develop new nanotechnologies in a responsible and sustainable manner; 2) How can it be ensured that nanomanufacturing processes are safe for producers and products are safe for consumers and the environment. This talk discusses NSF-supported projects in sustainable nanomanufacturing that address life-cycle analysis, recycling, environmentally-benign nanomaterials and processing, green nanomanufacturing, clean energy, wastewater treatment, among others. It will conclude with a discussion on future directions and their implications.