2, Group of Optoelectronic of Semiconductors and Nanomaterials,, ENSET, Mohammed V University, Rabat, , Morocco
Magnetic and fluorescent nanoparticles are widely studied in biomedical research for their use in drug delivery, cell separation, magnetic resonance imaging (MRI), hyperthermia, various multimodal techniques, etc. In this study, we report a recent work on nanoparticles incorporating with a fluorescent molecue and a superparamagnetic core via nanoscale engineering. Fe3O4-Au hybrid nanoparticles are synthesized via a solution phase chemical reaction in an inert N2 atmosphere. These synthesized hybrid nanoparticles are characterized by UV-Vis-NIR spectroscopy, fluorescence spectroscopy, XRD, TEM, etc. Optimal synthesis conditions are also highly relevant in producing stable and uniform hybrid nanoparticles without impurities. Fluorescence spectroscopy show the correlations between the lifetime and intensity of fluorescence and sizes, compositions, shapes of hybrid nanoparticles as well as the conjugation process to link the nanoparticles to fluorescent molecules. By carefully engineering the growth conditions, such as altering growth temperatures and precursor reagent ratios, functional hybrid magnetic nanoparticles can be optimized for hyperthermia, MRI and other multimodal biomedical applications.