The DOD currently faces a broad range of materials challenges. The changing geopolitical environment has created a need for agile supply chains of critical materials and components. The push for miniaturization and light-weighting has created a need for precise and scalable assembly of materials with limited defects. Additionally, the diverse and challenging operational environments faced by the warfighter has created a need for multifunctional materials that can sense and respond to the human and the surrounding environment. Strategic utilization of synthetic biology has the potential to provide new materials capabilities that can address many of these critical challenges. This talk will highlight work being done in synthetic biology at the Air Force Research Laboratory, Materials and Manufacturing Directorate to enable new solutions to these challenges. Specifically, new strategies and pipelines for the discovery and engineering of novel enzymes and proteins that can be used in the production of critical material components will be discussed.