Nitrogen (N) deficiency has been considered as the most important limiting factor for crop yield, explaining the high N fertilizer application worldwide. Among all the N-content molecules urea is the most used due to its high N content, however, its efficiency is limited by losses such as leaching and volatilization. For this reason, we propose the production of a fertilizer based in urea-melamine-thermoplastic starch using a one-step method aiming to control the nitrogen release as a nutrient. The extrusion process used has been showed to be a simple, continuous, high throughput method, capable to promote melamine incorporation, which was responsible to increase the interaction among urea and starch. The results reveal that melamine plays an important role as structure modifier, increasing the effective use of available N for plants in pot experiments. The characterization shows that this material is a polymeric blend, possible to be processed by continuous method (extrusion) leading a plastic granule, with high homogeneity and high nutrient contents. Pot trials (using maize) shown that this material increases the N efficiency (based in the actual available N) leading to a significant nutrient residual in soil useful for future cultures, confirming that this product might replace with advantages the conventional N fertilizers.