Date: 11-26-2018 - Monday - 08:00 PM - 10:00 PM
Ye Liu1 Catherine Dabrowska1 Lukas Vasadi1 Joo-Hyeon Lee1 Yan Yan Shery Huang1

1, Cambridge University, Cambridge, , United Kingdom

Organoids are stem-cell derived, self-organized micro tissues that mimic the basic structure and function of an organ unit. They have been shown to be instrumental for the studies of organ development, disease progression and personalized medicine. To-date, most organoid cultures are maintained in extracellular matrix-mimicking hydrogels in static environments, which lack the biomechanical stimuli experienced by living tissues. Although respiration-like motion has been successfully established in the membrane-based microfluidics, alternative chip designs are still being sought to expand the applications of 3D organoid-hydrogel cultures. With the aim to incorporate biomechanical cues for airway organoids, 3D printed micro-structures are designed to provide force and flow stimuli. These 3D printed microchips present reproducible geometry, and effective integration with a hydrogel-airway organoid model. The combination of 3D printed fluidic devices and organoid cultures can provide an alternative platform to simulate complex micro-organ environments.

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